Selected publication list

Larisch S., Youngsuk Yi, #Lotan R., Kerner H., Eimerl S., Parks W.T., #Gottfried Y., Birkey Reffey S., de Caestecker M.P., Danielpour D., Book-Melamed N., Timberg R.,  Duckett C.,  Lechleider R.J., Steller, H. Orly J., Kim  S-J. and A.B. Roberts (2000) ARTS, a novel mitochondrial septin-like protein, mediates apoptosis dependent on its P-loop motif.  Nature Cell Biology, 2:915-921. IF 2000 (JCR)=11.939 R= Biochemistry and Molecular Biology 2000= 11/310

#Gottfried Y., #Rotem A., #Lotan R., Steller H., and S. Larisch (2004) The mitochondrial ARTS protein promotes apoptosis through targeting XIAP. EMBO Journal.  23(7):1627-35.
IF 2004 (JCR)=10.492 R= Biochemistry and Molecular Biology 2004= 13/261

Elhasid R., Sahar D., Merling A., Zivony Y.,#Rotem A., Ben-Arush M., Izraeli S., Bercovich D., Larisch S. (2004) The mitochondrial pro-apoptotic ARTS protein is lost in the majority of Acute Lymphoblastic Leukemia patients.  Oncogene, 23(32): 5468-7. IF 2004 (JCR)=6.318 R= Oncology 2004= 11/123

#Gottfried Y., Vlodavsky E., Yodko L., Sabo E., Ben-Itzhak O., and S. Larisch (2004) Expression of the pro-apoptotic protein ARTS in astrocytic tumors: correlation with malignancy grade and survival rate. Cancer. 101(11): 2614-21. IF 2004 (JCR)=4.434 R= Oncology 2004= 22/123

Larisch, S. (2004) The ARTS Connection.  Role of ARTS in apoptosis and cancer. Cell Cycle, vol.3 issue 8.  2004 N/A IF 2006 (JCR)=3.214 R= Cell Biology 2006= 71/156

#Lotan R., #Rotem A., Finberg J. PM., Gonen H., Steller H., Ciechanover A. and S.Larisch (2005Regulation of the mitochondrial pro-apoptotic protein ARTS, through ubiquitin mediated proteasome degradation. Journal of Biological Chemistry 280(27):25802-10. IF 2005 (JCR)=5.854 R= Biochemistry and Molecular Biology 2005= 38/261

Kissel, H., Georgescu, M., Hunnicut, G., Larisch, S., and Steller, H. (2005) The Sept4 Septin Locus is required for Sperm Terminal Differentiation in Mice.  Developmental Cell, 8(3): 353-64. IF 2005 (JCR)=14.609 R= Cell Biology 2005= 8/153

#Carp MJ. and S. Larisch, Septins and Apoptosis in “The Septins”. P.281-294, Edited by Hall PA, Russell SEH, Pringle JR, Wiley Blackwell, London, 2008.

García-Fernández M., Kissel H., Brown S., Gorenc T., Schile A.J., Rafii S., Larisch S. and H. Steller (2010) Sept4/ARTS is required for stem cell apoptosis and tumor suppression. Genes &Development.  24(20):2282-93. IF 2010 (JCR)=12.889 R= Cell Biology 2010= 14/178

#Bornstein B., #Gottfried Y., #Edison N, #Shekhtman A., #Lev T., Glaser F. and Larisch S. (2011). ARTS binds to a distinct domain in XIAP-BIR3 and promotes apoptosis by a mechanism that is different from other IAP-antagonists. Apoptosis 16(9):869-81. IF 2011 (JCR)=4.788 R= Biochemistry and Molecular Biology 2011= 65/290

Elhasid R. and S. Larisch (2011) ARTS-based anticancer therapy: taking aim at cancer stem cells. Future Oncology 7: 1185-94. IF 2011 (JCR)=3.161 R= Oncology 2011= 75/196

Mandel-Gutfreund Y., Kosti I. and S. Larisch (2011ARTS, the unusual septin: structural and functional aspects. Journal of Biological Chemistry 392: 783-90. IF 2011 (JCR)=4.773 R= Biochemistry and Molecular Biology 2011= 66/290

# Reingewertz, T.H., Shalev E., Sukenik S., Blatt O., Rotem-Bamberger S., Lebendiker M., Larisch S. and A. Friedler (2011). Mechanism of the Interaction between the Intrinsically Disordered C-Terminus of the Pro-Apoptotic ARTS Protein and the Bir3 Domain of XIAP. PLoS One 6(9): e24655. IF 2011 (JCR)=4.092 R= Biology 2011= 12/85

#Bornstein, B., #Edison N., #Gottfried Y., #Lev T., #Shekhtman A., Gonen H., Rajalingam K. and S. Larisch (2012). “X-linked Inhibitor of Apoptosis Protein promotes the degradation of its antagonist, the pro-apoptotic ARTS protein.” International Journal of Biochemistry and Cell Biology 44(3): 489-95. IF 2012(JCR)=4.151 R= Biochemistry and Molecular Biology 2012= 67/290

#Edison, N., # Zuri D., #Maniv I, #Bornstein B., #T. Lev, #Gottfried Y., #Kemeny S, Garcia-Fernandez M., #Kagan J. and S. Larisch (2012). “The IAP-antagonist ARTS initiates caspase activation upstream of cytochrome C and SMAC/Diablo.” Cell Death &Differentiation 19(2): 356-68. IF 2012 (JCR) =8.371 R= Biochemistry and Molecular Biology 2012= 26/290

  #Kemeny, S., # Dery D., Loboda Y., # Rovner M., # Zuri D., # Lev T., Finberg J.P.M. and S. Larisch (2012) Parkin promotes degradation of the mitochondrial pro-apoptotic ARTS protein. PloS One. 7(7): e38837. IF 2012 (JCR) =3.73 R= Multidisciplinary science 2012= 7/56

#Edison N., # Reingewertz T. H., # Gottfried Y., # Lev T., # Zuri D., # Maniv I., # Carp M., Shalev G., Friedler A. and S. Larisch. (2012Peptides mimicking the unique ARTS-IAP-Binding-Motif (AIBM) can penetrate and kill cultured cancer cells. Clinical Cancer Research. 1;18(9):2569-78. IF 2012 (JCR)=7.837 R= Oncology 2012= 12/196,

*# Edison N., #Curtz Y., #Paland N., #Mamriev D., #Chorubczyk N., #Reingewertz T.H., #Kfir N., Morgenstern D., Kupervaser M., Kagan J., Kim H.T. and S. Larisch (2017) Degradation of Bcl-2 by XIAP and ARTS promotes apoptosis.  Cell Reports 21(2):442-454. IF 2017 (JCR)=8.032 R= Cell Biology 2017= 28/190

*# Mamriev D., and S. Larisch (2018) Another one bites the dust; ARTS enables degradation of Bcl-2 by XIAP. Molecular & Cellular Oncology, IF 2018 (JCR)=1.47 R= Oncology 2018= 121/230

 *# Abbas R. and S. Larisch (2020), Targeting XIAP for Promoting Cancer Cell Death-The Story of ARTS and SMAC. Cells. 9;9(3). IF 2018 (JCR)=5.656 R= Cell Biology 2018= 40/193

 *#Mamriev, D.; #Abbas, R.; Klinger, F.M.; #Kagan, J.K.; N.; Weidenfeld, K.; Sheppard, D.; Barkan, D. and S. Larisch. (2020) A small-molecule ARTS mimetic promotes apoptosis through degradation of both XIAP and Bcl-2. Cell Death & Disease, 11:483. IF 2018 (JCR)=5.959 R= Cell Biology 2018= 38/193

 *#Shahar N. and S. Larisch (2020) Inhibiting the inhibitors: The role of anti-apoptotic proteins in drug resistance of cancer cells. Drug. Res. Updates. 52:100712. IF 2020 (JCR)=18.5 R= Pharmacology and Pharmacy 2020= 7/357

 *#Abbas R, Larisch S. Killing by Degradation: Regulation of Apoptosis by the Ubiquitin-Proteasome-System. Cells. 2021 Dec 8;10(12):3465. IF 2020 (JCR)=6.6 R= Cell Biology 2020= 53/195