Selected publication list
Larisch S., Youngsuk Yi, Lotan R., Kerner H., Eimerl S., Parks W.T., Gottfried Y., Birkey Reffey S., de Caestecker M.P., Danielpour D., Book-Melamed N., Timberg R., Duckett C., Lechleider R.J., Steller, H. Orly J., Kim S-J. and A.B. Roberts (2000) ARTS, a novel mitochondrial septin-like protein, mediates apoptosis dependent on its P-loop motif. Nature Cell Biology, 2:915-921. IF 2000 (JCR)=11.939 R= Biochemistry and Molecular Biology 2000= 11/310
Gottfried Y., Rotem A., Lotan R., Steller H., and S. Larisch (2004) The mitochondrial ARTS protein promotes apoptosis through targeting XIAP. EMBO Journal. 23(7):1627-35.
IF 2004 (JCR)=10.492 R= Biochemistry and Molecular Biology 2004= 13/261
Elhasid R., Sahar D., Merling A., Zivony Y.,Rotem A., Ben-Arush M., Izraeli S., Bercovich D., Larisch S. (2004) The mitochondrial pro-apoptotic ARTS protein is lost in the majority of Acute Lymphoblastic Leukemia patients. Oncogene, 23(32): 5468-7. IF 2004 (JCR)=6.318 R= Oncology 2004= 11/123
Gottfried Y., Vlodavsky E., Yodko L., Sabo E., Ben-Itzhak O., and S. Larisch (2004) Expression of the pro-apoptotic protein ARTS in astrocytic tumors: correlation with malignancy grade and survival rate. Cancer. 101(11): 2614-21. IF 2004 (JCR)=4.434 R= Oncology 2004= 22/123
Larisch, S. (2004) The ARTS Connection. Role of ARTS in apoptosis and cancer. Cell Cycle, vol.3 issue 8. 2004 N/A IF 2006 (JCR)=3.214 R= Cell Biology 2006= 71/156
Lotan R., Rotem A., Finberg J. PM., Gonen H., Steller H., Ciechanover A. and S.Larisch (2005) Regulation of the mitochondrial pro-apoptotic protein ARTS, through ubiquitin mediated proteasome degradation. Journal of Biological Chemistry 280(27):25802-10. IF 2005 (JCR)=5.854 R= Biochemistry and Molecular Biology 2005= 38/261
Kissel, H., Georgescu, M., Hunnicut, G., Larisch, S., and Steller, H. (2005) The Sept4 Septin Locus is required for Sperm Terminal Differentiation in Mice. Developmental Cell, 8(3): 353-64. IF 2005 (JCR)=14.609 R= Cell Biology 2005= 8/153
Carp MJ. and S. Larisch, Septins and Apoptosis in “The Septins”. P.281-294, Edited by Hall PA, Russell SEH, Pringle JR, Wiley Blackwell, London, 2008.
García-Fernández M., Kissel H., Brown S., Gorenc T., Schile A.J., Rafii S., Larisch S. and H. Steller (2010) Sept4/ARTS is required for stem cell apoptosis and tumor suppression. Genes &Development. 24(20):2282-93. IF 2010 (JCR)=12.889 R= Cell Biology 2010= 14/178
Bornstein B., Gottfried Y., Edison N, Shekhtman A., Lev T., Glaser F. and Larisch S. (2011). ARTS binds to a distinct domain in XIAP-BIR3 and promotes apoptosis by a mechanism that is different from other IAP-antagonists. Apoptosis 16(9):869-81. IF 2011 (JCR)=4.788 R= Biochemistry and Molecular Biology 2011= 65/290
Elhasid R. and S. Larisch (2011) ARTS-based anticancer therapy: taking aim at cancer stem cells. Future Oncology 7: 1185-94. IF 2011 (JCR)=3.161 R= Oncology 2011= 75/196
Mandel-Gutfreund Y., Kosti I. and S. Larisch (2011) ARTS, the unusual septin: structural and functional aspects. Journal of Biological Chemistry 392: 783-90. IF 2011 (JCR)=4.773 R= Biochemistry and Molecular Biology 2011= 66/290
Reingewertz, T.H., Shalev E., Sukenik S., Blatt O., Rotem-Bamberger S., Lebendiker M., Larisch S. and A. Friedler (2011). Mechanism of the Interaction between the Intrinsically Disordered C-Terminus of the Pro-Apoptotic ARTS Protein and the Bir3 Domain of XIAP. PLoS One 6(9): e24655. IF 2011 (JCR)=4.092 R= Biology 2011= 12/85
Bornstein, B., Edison N., Gottfried Y., Lev T., Shekhtman A., Gonen H., Rajalingam K. and S. Larisch (2012). “X-linked Inhibitor of Apoptosis Protein promotes the degradation of its antagonist, the pro-apoptotic ARTS protein.” International Journal of Biochemistry and Cell Biology 44(3): 489-95. IF 2012(JCR)=4.151 R= Biochemistry and Molecular Biology 2012= 67/290
Edison, N., Zuri D., Maniv I, Bornstein B., T. Lev, Gottfried Y., Kemeny S, Garcia-Fernandez M., Kagan J. and S. Larisch (2012). “The IAP-antagonist ARTS initiates caspase activation upstream of cytochrome C and SMAC/Diablo.” Cell Death &Differentiation 19(2): 356-68. IF 2012 (JCR) =8.371 R= Biochemistry and Molecular Biology 2012= 26/290
Kemeny, S., Dery D., Loboda Y., Rovner M., Zuri D., Lev T., Finberg J.P.M. and S. Larisch (2012) Parkin promotes degradation of the mitochondrial pro-apoptotic ARTS protein. PloS One. 7(7): e38837. IF 2012 (JCR) =3.73 R= Multidisciplinary science 2012= 7/56
Edison N., Reingewertz T. H., Gottfried Y., Lev T., Zuri D., Maniv I., Carp M., Shalev G., Friedler A. and S. Larisch. (2012) Peptides mimicking the unique ARTS-IAP-Binding-Motif (AIBM) can penetrate and kill cultured cancer cells. Clinical Cancer Research. 1;18(9):2569-78. IF 2012 (JCR)=7.837 R= Oncology 2012= 12/196,
Edison N., Curtz Y., Paland N., Mamriev D., Chorubczyk N., Reingewertz T.H., Kfir N., Morgenstern D., Kupervaser M., Kagan J., Kim H.T. and S. Larisch (2017) Degradation of Bcl-2 by XIAP and ARTS promotes apoptosis. Cell Reports 21(2):442-454. IF 2017 (JCR)=8.032 R= Cell Biology 2017= 28/190
Mamriev D., and S. Larisch (2018) Another one bites the dust; ARTS enables degradation of Bcl-2 by XIAP. Molecular & Cellular Oncology, IF 2018 (JCR)=1.47 R= Oncology 2018= 121/230
Abbas R. and S. Larisch (2020), Targeting XIAP for Promoting Cancer Cell Death-The Story of ARTS and SMAC. Cells. 9;9(3). IF 2018 (JCR)=5.656 R= Cell Biology 2018= 40/193
Mamriev, D.; Abbas, R.; Klinger, F.M.; Kagan, J.K.; N.; Weidenfeld, K.; Sheppard, D.; Barkan, D. and S. Larisch. (2020) A small-molecule ARTS mimetic promotes apoptosis through degradation of both XIAP and Bcl-2. Cell Death & Disease, 11:483. IF 2018 (JCR)=5.959 R= Cell Biology 2018= 38/193
Shahar N. and S. Larisch (2020) Inhibiting the inhibitors: The role of anti-apoptotic proteins in drug resistance of cancer cells. Drug. Res. Updates. 52:100712. IF 2020 (JCR)=18.5 R= Pharmacology and Pharmacy 2020= 7/357
Abbas R, Larisch S. Killing by Degradation: Regulation of Apoptosis by the Ubiquitin-Proteasome-System. Cells. 2021 Dec 8;10(12):3465. IF 2020 (JCR)=6.6 R= Cell Biology 2020= 53/195
Maimon N., Zamir Z.Z., Kalkar P., Zeytuni-Timor O., Schif-Zuck S., Larisch S. and A. Ariel. (2020) The pro-apoptotic ARTS protein induces neutrophil apoptosis, efferocytosis, and macrophage reprogramming to promote resolution of inflammation. Apoptosis. 25(7): 558-573.
Larisch S (2021) The “ARTS” of Cell Death in Service of Life: How Do We Force Cancer Cells to Commit Suicide? Frontiers Young Minds 9:633011.
Hao Q., Chen J., Liao J., Huang Y., Larisch S., Zeng S.X., Lu H. and X. Zho. (2021) p53 induces ARTS to promote mitochondrial apoptosis. Cell Death & Disease, 12(2): 204
Choo, Z., Koh, X., Wong, M. R. E., Ashokan, R. M., Ali Ahamed, N. S. B., Kang, C., Kuick, C. H., Chang, K. T. E., Larisch, S., Loh, A. H. P., & Chen, Z. X. Targeted Degradation of XIAP is Sufficient and Specific to Induce Apoptosis in MYCN-overexpressing High-risk Neuroblastoma. Cancer Research Communications (2023); 3 (11): 2386–2399.
Abbas R, Hartmann O, Asiss D, Abbas R, Kagan J, Kim H-T, Oren M, Diefenbacher M, Orian A and S. Larisch. (2024) ARTS and small-molecule ARTS mimetics upregulate p53 levels by promoting the degradation of XIAP. Apoptosis, 2024 Aug;29(7-8):1145-1160.